How to Compound Your Own Low Dose Naltrexone (LDN)


Low Dose Naltrexone (LDN) is a powerful anti-inflammatory, immune modulating drug therapy that can be a “game changer” for people with physical or neurological chronic inflammation. However, it can be a bit “high maintenance” and expensive for patients to find the right dose. Traditionally, you would go to a doctor ($$) and get a prescription for LDN, get it filled at a compounding pharmacy ($$) that weighs out a custom capsule or tablet in your exact prescribed dose, take that initial dose a few weeks or months, then go back for another doctors visit ($$) to get the dose adjusted, then back to the compounding pharmacy for a newly dosed formula ($$), etc, etc.

If you are comfortable compounding & titrating the drug yourself, making your own LDN out of 50mg naltrexone tablets is really simple. And affordable! Here’s how:

Materials needed:

  • 2 x naltrexone 50mg tablets (generic)
  • 500mL bottle of sealed bottled water
  • 30mL graduated shot glass


  1. Drop two 50mg naltrexone tablets into a 500mL bottle of water.
  2. Let tablets dissolve for 30 minutes and then shake vigorously.
  3. When fully and completely dissolved (some tiny white sediments of tablet binder will remain), shake bottle & pour the desired dose into a shot glass and consume.
  4. Store the bottle in the refrigerator for cleanest & best results.
Milliliters of LiquidApproximate Dose of LDN
5 mL1 mg
10 mL2 mg
15 mL3 mg
20 mL4 mg
25 mL5mg

The inventor of LDN therapy, Dr. Bernard Bihari, has been quoted as saying LDN must be taken at bedtime for it to work and cause proper endorphin release.

I and others have found it works fine if taken at any time of the day or night. I pour out my dose before bedtime and take my LDN “shot” upon awakening.


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